803110 Biointerfaces, biomaterials and biophysics in nanobiosciences (in Eng.)

Vortragende/r (Mitwirkende/r)
Toca-Herrera, José Luis , Reimhult, Erik
Institut für Biophysik
Angeboten im Semester
Wintersemester 2017/18
Unterrichts-/ Lehrsprachen


This lecture series provides a detailed overview of man-made organic and inorganic biomaterials, with emphasis on the interaction of solid materials with biological systems. The students will start from the basic principles guiding interaction of biomolecules with each other and foreign materials to build an understanding of the hierarchy of events that determines the fate of biomaterials (e.g. implants, biosensors and drug delivery vehicles) from the molecular to the tissue level. Particular focus is on understanding techniques used to characterize biomaterial interfaces and interactions, and how they influence our current understanding of biomaterial performance and design. The course further in detail covers strategies and state-of-the-art solutions to control the biological response of materials and surfaces using biological and synthetic surface modifications. The students will learn how to apply and evaluate such strategies to applications ranging from implants, to biosensors and anti-fouling (anti-microbial) surfaces. A particular section of the course will deal with the design and interaction of nanomaterials with biological environments, e.g. the design of nanomaterial properties for drug delivery, imaging and biosensing.

Inhaltliche Voraussetzungen (erwartete Kenntnisse)

Basic knowledge in Biochemistry, Chemistry and Physics.


After the course the students will have a detailed understanding of the physical and chemical principles guiding biomolecular interactions with interfaces, and how biointerfaces form with foreign matter over many length scales (molecular to tissue). They will understand the evaluation criteria for controlling the responses of materials with biological and medical applications and to critically assess techniques used for their characterization. The students will acquire state-of-the-art knowledge of strategies to control the biological response of implants, anti-microbial interfaces and biosensors. In particular, the students will be introduced to the physical and chemical design of nanomaterials for biomedical and biotechnological applications ranging from biosensors to in vivo application of drug delivery vehicles and imaging contrast agents.
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