Best Poster Award Elisabeth Lobner
Her poster describes the construction of antibody fragments (Fcabs) binding to the antigen HER2 in a pH dependent manner.
Overexpression of HER2 is known to be involved in the development of the most abundant types of breast cancer. The idea of this project was to decrease the affinity to HER2 at endosomal pH in order to reduce the degradation of the fragments and thus increase their half-life by recycling to the cell surface, where further antigen can be bound.
The work was published in the Biotechnology Journal: www.ncbi.nlm.nih.gov/pubmed/24964247
This work is supported by the Christian Doppler Laboratory for Antibody Engineering and the PhD program „BioToP – Biomolecular Technology of Proteins“ and supervised by Dr. Michael Traxlmayr and Prof. Christian Obinger.
Website of the PhD program BioToP: