RESEARCH GROUP ORGANIC CHEMISTRY

Universitaet fuer Bodenkultur Wien
University of Agricultural Sciences Vienna

• Synthesis and conformational aspects of complex carbohydrates
  

• NMR-spectroscopy
  
  
  • Informations about our NMR CUSTOM SERVICE
  
  

• Artificial antigens and haptens
  

• Synthesis of nucleotide activated sugars
  

• Investigation of the biosynthesis of bacterial heptoses and development of potential inhibitors
  

Within the last decade research interests were focussed on the chemical synthesis of inner core and Lipid A structures of bacterial lipopolysaccharides as well as capsular polysaccharides and their conversion into artificial antigens which resulted in the practical application for the clinical diagnosis of chlamydial infections.
Current research interests are devoted to the development of protective antibodies against gram-negative bacteria responsible for septic shock syndrome: Furthermore, inhibition of the biosynthetic pathway of the vitally essential core-region (inhibitors of Kdo transferases) may lead to novel antibiotics
Future aspects will cover conformational studies by molecular modelling, x-ray cristallography of kdo-oligosaccharides and of cocrystals obtained with synthetic ligands and Fab fragments of monoclonal antibodies as well as novel chemical strategies for the synthesis of complex oligosaccharides and supramolecular antigens.
Structural analysis and conformational studies for both people inside and outside the BOKU is another topic of interest.


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Address:  Muthgasse 18;
A-1190 Vienna
Austria/EUROPE


Tel:         +43 1 36006/6055 or 6057 (Secretary)
FAX:      +43 1 36006/6059

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